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Cat. No. Name Size Price Add Cart
KI3746ML16110 mg$250
ML16150 mg$800

Chemical Characteristic

Product NameML161
CAS No.423735-93-7
Molecular Weight 361.23
FormulaC17H17BrN2O2
SmilesC(=O)(c1c(cccc1)Br)Nc1cc(ccc1)NC(=O)CCC
Chemical Structure

Biological activities

ML-161 is an allosteric inhibitor of PAR1 with IC50 0.26?M. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs [1].

References

[1] Dockendorff C, Aisiku O, Verplank L, et al. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. ACS Med Chem Lett. 2012,3(3):232-237.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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