Cat. No. Name Size Price Add Cart
KI2580ML20410 mg$325
ML20450 mg$1287

Chemical Characteristic

Product NameML204
CAS No.5465-86-1
Molecular Weight 226.32
FormulaC15H18N2
Chemical Name4-methyl-2-(piperidin-1-yl)quinoline
Smilesn1c(cc(c2ccccc12)C)N1CCCCC1
Chemical Structure

Biological activities

ML204 is a potent and selective TRPC4 channel inhibitor. ML204 inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 of 0.96 μM. Meanwhile, ML204 blocks membrane depolarization signal with an IC50 of 18.4 μM. In vitro, ML204 inhibits endogenous M3 muscarinic receptors in HEK293 cells. Furthermore, ML204 specifically inhibits the TRPC4 components of mICAT in intestinal smooth muscle cells.[1]

Protocols

In vitro, ML204 is dissolved in DMSO.[1]

References

[1] Melissa Miller, et al. Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels. J Biol Chem. 2011, 286 (38): 33436-33446.

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