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Cat. No. Name Size Price Add Cart
KI3112MLN-22385 mg$272
MLN-223810 mg$512
MLN-2238200 mg$3952

Chemical Characteristic

Product NameMLN-2238
CAS No.1072833-77-2
Molecular Weight 361.03
FormulaC14H19BCl2N2O4
Chemical Name[(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acid
Smiles[C@H](CC(C)C)(B(O)O)NC(=O)CNC(=O)c1c(ccc(c1)Cl)Cl
Chemical Structure

Biological activities

MLN2238 is a selective, potent, and reversible inhibitor of the proteasome. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM. Meanwhile, MLN2238 also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50s of 31 and 3500 nM, respectively. In vivo, MLN2238 shows antitumor activity in the CWR22 xenograft model, and induces a greater pharmacodynamic response than bortezomib in xenograft tumors.[1]

Protocols

In vivo, MLN2238 is dissolved in DMSO.[1]

References

[1]Kupperman E, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010, 70(5): 1970-1980.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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