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Cat. No. Name Size Price Add Cart
KI3700MPEP Hydrochloride10 mg$164
MPEP Hydrochloride50 mg$460

Chemical Characteristic

Product NameMPEP Hydrochloride
CAS No.219911-35-0
Molecular Weight 229.7
FormulaC14H12ClN
Smilesc1ccc(cc1)C#Cc1cccc(n1)C Cl
Chemical Structure

Biological activities

MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, and it exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors [1]. MPEP has no appreciable agonist or antagonist activity at the closely related recombinant human mGlu1b receptor expressed in CHO-K1 cells or a purinoreceptor endogenously expressed in L(tk-) cells up to concentrations of 100 ?M. MPEP inhibits DHPG-stimulated PI hydrolysis with IC50 of 8.0 nM, 20.5 nM, and 17.9 nM, respectively. MPEP positively modulates the hmGluR4 in a recombinant expression system, and the effect of MPEP is fully dependent on the activation of the orthosteric agonist L-AP4 [2]. In vivo, it can be used by 2.5-30 mg/kg/day in rats [3].

References

[1] Kumar J, Hapidin H, Bee YT, et al. Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats. Behav Brain Funct. 2013, 9(43).
[2] Morin N, Morissette M, Gr?goire L, et al. Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. Neuropharmacology. 2013, 73:216-231.
[3] Gandhi RM, Kogan CS, Messier C. 2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice. Front Cell Neurosci. 2014, 6(8):70.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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