Mycophenolate mofetil Inhibitor CAS No. 128794-94-5

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Mycophenolate-mofetil

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Cat. No.	Name	Size	Price
KI0811	Mycophenolate mofetil	50 mg	$154
	Mycophenolate mofetil	100 mg	$272
	Mycophenolate mofetil	200 mg	$432

Chemical Characteristic

Product Name	Mycophenolate mofetil
Synonyms	CellCept
CAS No.	128794-94-5
Molecular Weight	433.49
Formula	C₂₃H₃₁NO₇
Chemical Structure

Biological activities

Mycophenolate mofetil is a reversible inhibitor of inosine monophosphate dehydrogenase in purine biosynthesis (specifically guanine synthesis). Mycophenolate mofetil is an immunosuppressant and prodrug of mycophenolic acid. Mycophenolate mofetil inhibits the proliferation of lymphocytes and the production of antibodies induced by a variety of mitogens and antigens.^[1] Mycophenolate mofetil inhibits mitogen-induced rat mesangial cells and human mesangial cells proliferation with IC50 value of 450 and 190 nM, respectively.^[2] Mycophenolate mofetil inhibits human Tenon fibroblasts proliferation in a does-dependent manner. Brief exposure to mycophenolate mofetil leads to a reversible growth arrest for up to 14 days with concentrations of 1 mM or higher.^[3] In Lewis rats in vivo, mycophenolate mofetil treatment (5, 10 or 20 mg/kg) inhibits lymphocyte proliferation and surface antigen expression in a does-dependent manner.^[4] Furthermore, when given perorally at 200 mg/kg of body weight/day, mycophenolate mofetil potentiates to some extent the growth retardation induced by GCV in young NMRI mice.^[5]

Protocols

In vivo: Mycophenolate mofetil is dissolved in water.^[6]

References

[1] Fulton B, et al. Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation. Drugs. 1996, 51(2): 278-298. 閵嗏偓閵嗏偓 [2] Hauser IA, et al. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion. Nephrol Dial Transplant. 1999, 14(1): 58-63. 閵嗏偓閵嗏偓 [3] Heinz C, et al. Antiproliferative effect of mycophenolate mofetil on cultured human Tenon fibroblasts. Graefes Arch Clin Exp Ophthalmol. 2002, 240(5): 408-414. 閵嗏偓閵嗏偓 [4] Barten MJ, et al. Novel assays of multiple lymphocyte functions in whole blood measure: new mechanisms of action of mycophenolate mofetil in vivo. Transpl Immunol. 2002, 10(1): 1-14. 閵嗏偓閵嗏偓 [5] Neyts J, et al. The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo. Antimicrob Agents Chemother. 1998, 42(2): 216-222. 閵嗏偓閵嗏偓 [6] R?is?nen-Sokolowski A, et al. Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts. Transpl Immunol. 1995, 3(4): 342-351.

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