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Cat. No. Name Size Price Add Cart
KI3771Nebivolol hydrochloride10 mg$164

Chemical Characteristic

Product NameNebivolol hydrochloride
CAS No.152520-56-4
Molecular Weight 441.9
FormulaC22H26ClF2NO4
SmilesN(C[C@@H]([C@@H]1CCc2cc(ccc2O1)F)O)C[C@@H]([C@H]1CCc2cc(ccc2O1)F)O Cl
Chemical Structure

Biological activities

Nebivolol hydrochloride is the hydrochloride salt preparation of Nebivolol??hich is a highly selective beta(1)-adrenoceptor antagonist (?1-adrenoceptor Ki = 0.88 nM, ?2-adrenoceptor Ki = 48 nM, ?1-adrenergic Ki = 1160 nM, serotonin 5-HT1A Ki = 20 nM, 5-HT2 Ki = 700 nM, dopamine D2 Ki = 4000 nM, histamine H1 Ki = 2400 nM). Nebivolol produces vasodilation through inducing vascular production of NO, mediated through Nebivolol agonism of the ?3-adrenoceptor and shows antihypertensive activity in vivo [1,2].

References

[1] Pauwels PJ, Gommeren W, Van Lommen G, et al. The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various ?-adrenergic blockers. Mol.Pharmacol. 1988, 34(6):843-851.
[2] Georgescu A, Pluteanu F, Flonta ML, et al. Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology. 2008,81(2):110-117

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