Cat. No. Name Size Price Add Cart
KI3665Necrostatin-110 mg$156
Necrostatin-150 mg$280
Necrostatin-1100 mg$432

Chemical Characteristic

Product NameNecrostatin-1
CAS No.4311-88-0
Molecular Weight 259.33
FormulaC13H13N3OS
Chemical Name5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
SmilesC1(=S)N(C(=O)C(N1)Cc1c[nH]c2c1cccc2)C
Chemical Structure

Biological activities

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-?-induced necroptosis with EC50 of 490 nM [1]. Necrostatin-1 is an inhibitor of necroptosis, a mechanism of programmed cell death separated from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway [2]. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. In vitro, it can be used by 1000 nM in jurket cells [3].

References

[1]. Han W, Xie J, Li L, et al. Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis. 2009,14(5):674-86.
[2]. Qinli Z, Meiqing L, Xia J, et al. Necrostatin-1 inhibits the degeneration of neural cells induced by aluminum exposure. Restor Neurol Neurosci. 2013, 31(5):543-555.
[3]. Pan T, Wu S, He X, et al. Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes. PLoS One. 2014, 9(4):e93944.

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