Nepafenac Inhibitor CAS No. 78281-72-8

Cat. No.	Name	Size	Price
KI0932	Nepafenac	10 mg	$192
	Nepafenac	25 mg	$336
	Nepafenac	100 mg	$1232

Chemical Characteristic

Product Name	Nepafenac
CAS No.	78281-72-8
Molecular Weight	254.28
Formula	C₁₅H₁₄N₂O₂
Chemical Structure

Biological activities

Nepafenac is a selective cyclooxygenase閳? (COX閳?) inhibitor. Nepafenac is metabolized into amfenac which inhibits COX-2 with an IC50 of 1.8 nM. ^[1] Nepafenac inhibits the proliferation of uveal melanoma cell.^[2] Nepafenac improves the function of macrophages suppressed by uveal melanoma conditioned medium.^[3] 0.5% nepafenac produces 65% reduction in retinal edema which is correlated with 62% inhibition of blood-retinal barrier breakdown.^[1] 0.1% or 0.5% nepafenac has significantly less choroida neovascularization and significant less ischemia-induced retinal neovascularization in mice.^[4]

Protocols

In vitro Nepafenac is dissolved in DMSO.^[1]

References

[1] Walters T, et al. In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J Cataract Refract Surg. 2007, 33(9): 1539-1545. [2] Marshall JCA, et al. Inhibition of uveal melanoma cell proliferation by nepafenac, a selective cyclooxygenase閳? (COX閳?) inhibitor. Invest Ophthalmol Vis Sci. 2004, 45: E-Abstract 1204. 閵嗏偓閵嗏偓 [3] Caissie AL, et al. The Cyclooxygenase閳? inhibitor nepafenac improves the function of macrophages suppressed by uveal melanoma conditioned medium. Invest Ophthalmol Vis Sci. 2005, 46: E-Abstract 3407. 閵嗏偓閵嗏偓 [4] Takahashi K, et al. Topical nepafenac inhibits ocular neovascularization. Invest Ophthalmol Vis Sci. 2003, 44(1): 409-415. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.