Nevirapine Inhibitor CAS No. 129618-40-2

Cat. No.	Name	Size	Price	Add Cart
KI0814	Nevirapine	5 mg	$112
KI0814	Nevirapine	25 mg	$432

Chemical Characteristic

Product Name	Nevirapine
Synonyms	Viramune
CAS No.	129618-40-2
Molecular Weight	266.3
Formula	C₁₅H₁₄N₄O
Chemical Structure

Biological activities

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). The IC50 of nevirapine is 280 nM for HIV-1 reverse transcriptase.^[1] Nevirapine is used to treat HIV-1 infection and AIDS. Nevirapine is not effective against HIV-2. Resistance to nevirapine develops rapidly if viral replication is not completely suppressed.^[2] The most common mutations observed after nevirapine treatment are Y181C and K103N, which are also observed with other NNRTIs.^[3] Nevirapine is the most permeable antiretroviral agent compared to other HIV antiretroviral agents (such as didanosine, stavudine, zalcitabine and zidovudine) studied in the in vitro blood-brain barrier (BBB) model.^[4] Nevirapine also induces extensive reprogramming of gene expression in hormone-refractory human prostate carcinoma cells in vitro. Furthermore, nevirapine down-regulates the growth of prostate carcinoma xenografts in athymic mice and induces a differentiated phenotype in vivo with increased K18 expression.^[5]

Protocols

In vivo: Nevirapine is dissolved in DMSO.^[6]

References

[1] Ahn MJ, et al. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull. 2004, 27(4): 544-547. 閵嗏偓閵嗏偓 [2] Montaner JS, et al. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study. JAMA. 1998, 279(12): 930-937. 閵嗏偓閵嗏偓 [3] Conway B, et al. Development of drug resistance in patients receiving combinations of zidovudine, didanosine and nevirapine. AIDS. 2001, 15(10): 1269-1274. 閵嗏偓閵嗏偓 [4] Glynn SL, et al. In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J Pharm Sci. 1998, 87(3): 306-310. 閵嗏偓閵嗏偓 [5] Landriscina M, et al. Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009, 69(7): 744-754. 閵嗏偓閵嗏偓 [6] Hollanders RM, et al. Determination of nevirapine, an HIV-1 non-nucleoside reverse transcriptase inhibitor, in human plasma by reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 2000, 744(1): 65-71. 閵嗏偓閵嗏偓

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