Nicorandil Inhibitor CAS No. 65141-46-0

Cat. No.	Name	Size	Price	Add Cart
KI0798	Nicorandil	50 mg	$154

Chemical Characteristic

Product Name	Nicorandil
Synonyms	SG-75
CAS No.	65141-46-0
Molecular Weight	211.17
Formula	C₈H₉N₃O₄
Chemical Structure

Biological activities

Nicorandil is a potent vasodilator. Nicorandil relaxes vascular smooth muscle, at least in part, through cGMP.^[1] Nicorandil inhibits tension in vascular (rabbit portal vein) with an IC50 of 1.3 µM.^[2] Nicorandil reduces postischemic contractile dysfunction produced by a brief period of ischemia (myocardial stunning). Nicorandil significantly reduces mean aortic blood pressure (BP) and the rate-pressure product (RPP) which persists throughout the occlusion period. In addition, nicorandil markedly accelerates recovery of segment shortening in the ischemic/reperfused region as compared with control dogs.^[3] Nicorandil (30 µM) abolishes early after depolarizations (EADs) provoked by superfusion with Tyrode solution containing 2.7 mM K⁺ and 3 mM Cs. Nicorandil produces significant hyperpolarization only when automaticity occurred from the depolarized level of potential.^[4] Nicorandil increases coronary blood flow predominantly.^[5]

Protocols

In vivo: Nicorandil is dissolved in 0.9% NaC1 to give a concentration of 100 mM.^[5]

References

[1] Holzmann S. Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75). J Cardiovasc Pharmacol. 1983, 5(3): 364-370. 閵嗏偓閵嗏偓 [2] Longman SD, et al. Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J Cardiovasc Pharmacol. 1988, 12(5): 535-542. [3] Auchampach JA, et al. Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. J Cardiovasc Pharmacol. 1992, 20(5): 765-771. 閵嗏偓閵嗏偓 [4] Lathrop DA, et al. In vitro cardiac models of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil. Br J Pharmacol. 1990, 99(1): 119-123. 閵嗏偓閵嗏偓 [5] Yoneyama F, et al. Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism. Cardiovasc Drugs Ther. 1990, 4(4): 1119-1126. 閵嗏偓閵嗏偓

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