Nisoldipine Inhibitor CAS No. 63675-72-9

Cat. No.	Name	Size	Price	Add Cart
KI0686	Nisoldipine	50 mg	$154

Chemical Characteristic

Product Name	Nisoldipine
Synonyms	Sular, BAY-k 5552
CAS No.	63675-72-9
Molecular Weight	388.41
Formula	C₂₀H₂₄N₂O₆
Chemical Structure

Biological activities

Nisoldipine is a calcium channel blocker of the dihydropyridine class. The IC50 of nisoldipine is 0.016 nM against basal tension.^[1] In rat portal vein, nisoldipine concentration-dependently reduces the development of mechanical activity with an IC50 of 85 nM.^[2] Nisoldipine concentration-dependently depresses the maximum effect of 5-HT on the coronary artery preparations.^[3] Nisoldipine treatment in vitro significantly decreases [Ca²⁺]i, and significantly improves RBC-df.^[4] In SA node preparations, nisoldipine reduces sinus rate and produces atrial standstill. ^[5] Nisoldipine also inhibits platelet aggregation mechanisms other than by alpha 2-adrenoceptor blockade.^[6]

Protocols

In vivo: Nisoldipine is dissolved in 15% ethanol, 15% polyethylene glycol 400, 70% distilled water.^[5]

References

[1] Smith JM, et al. Calcium antagonists inhibit elevated potassium efflux from aorta of aldosterone-salt hypertensive rats. Hypertension. 1990, 15(1): 78-83. 閵嗏偓閵嗏偓 [2] Chulia T, et al. Comparative study of elgodipine and nisoldipine on the contractile responses of various isolated blood vessels. Eur J Pharmacol. 1995, 285(2): 115-122. 閵嗏偓閵嗏偓 [3] Pfaffendorf M, et al. In vitro effects of nifedipine, nisoldipine, and lacidipine on rat isolated coronary small arteries. J Cardiovasc Pharmacol. 1993, 21(3): 496-502. 閵嗏偓閵嗏偓 [4] Fujita J, et al. Nisoldipine improves the impaired erythrocyte deformability correlating with elevated intracellular free calcium-ion concentration and poor glycaemic control in NIDDM. Br J Clin Pharmacol. 1999, 47(5): 499-506. 閵嗏偓閵嗏偓 [5] Takahashi K, et al. Cardiovascular profiles of the calcium antagonists nisoldipine and nifedipine in the blood-perfused dog heart. Arzneimittelforschung. 1986, 36(7): 1054-1059. 閵嗏偓閵嗏偓 [6] Jones CR, et al. Effects of verapamil and nisoldipine on human platelets: in vivo and in vitro studies. Br J Clin Pharmacol. 1985, 20(3): 191-196. 閵嗏偓閵嗏偓

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