Nitrofurazone Inhibitor CAS No. 59-87-0

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KI0741	Nitrofurazone	10 mg	$530
KI0741	Nitrofurazone	25 mg	$900

Chemical Characteristic

Product Name	Nitrofurazone
Synonyms	Actin-N,Furacin, Furacilin, Nitrofural
CAS No.	59-87-0
Molecular Weight	198.14
Formula	C₆H₆N₄O₄
Chemical Structure

Biological activities

Actin-N is a bactericidal agent used as an antibiotic. The IC50 of actin-N is 22.83 µM in vitro cruzain inhibition tests.^[1] Actin-N suppresses human porphobilinogen synthase with an IC50 of 2.1 µM.^[2] Actin-N increases chromosomal damage.^[3] Actin-N significantly inhibits RNA synthesis.^[4] Actin-N inhibits DNA replication.^[5] In the presence of the oxygen-sensitive reductase, actin-N stimulates superoxide formation and oxygen consumption.^[6] Actin-N produces damages to mammalian cell DNA.^[7] Actin-N produces testicular degeneration (atrophy of germinal epithelium and aspermatogenesis) in F344/N rats. In B6C3F1 female mice, actin-N induces ovarian lesions with increased incidences of benign mixed tumours.^[8]

Protocols

In vitro. Actin-N is dissolved in DMSO.^[7]

References

[1] Trossini GH, et al. Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi. J Enzyme Inhib Med Chem. 2010, 25(1): 62-67. 閵嗏偓閵嗏偓 [2] Lawrence SH, et al. Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme. ChemMedChem. 2011, 6(6): 1067-1073. 閵嗏偓閵嗏偓 [3] Anderson D, et al. Nitrofurazone--genotoxicity studies in mammalian cells in vitro and in vivo. Food Chem Toxicol. 1985, 23(12): 1091-1098. 閵嗏偓閵嗏偓 [4] Plant CW, et al. Effect of tinidazole, metronidazole and nitrofurazone on nucleic acid synthesis in Clostridium bifermentans. J Antimicrob Chemother. 1976, 2(2): 203-209. 閵嗏偓閵嗏偓 [5] Ona KR, et al. Nucleotide excision repair is a predominant mechanism for processing nitrofurazone-induced DNA damage in Escherichia coli. J Bacteriol. 2009, 191(15): 4959-4965. 閵嗏偓閵嗏偓 [6] Peterson FJ, et al. Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. J Biol Chem. 1979, 254(10): 4009-4014. 閵嗏偓閵嗏偓 [7] Olive PL, et al. Damage to mammalian cell DNA by nitrofurans. Cancer Res. 1975, 35(3): 781-784. [8] Kari FW, et al. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989, 27(2): 129-137. 閵嗏偓閵嗏偓

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