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Cat. No. Name Size Price Add Cart
KI0636NS3985 mg$222

Chemical Characteristic

Product NameNS398
CAS No.123653-11-2
Molecular Weight 314.36
FormulaC13H18N2O5S
Chemical Structure

Biological activities

NS-398 is a novel anti-inflammatory and analgesic agent. NS-398 is a selective cyclooxygenase (COX)-2 inhibitor. [1] NS-398 inhibits COX-1 and COX-2, with IC50s of 9.2 and 0.08 µM, respectively. And the ratio of COX-1 to COX-2 is >100. [2] NS-398 enhances radio-sensitivity in H460 and RIE-S cells in a concentration-dependent manner. NS-398 enhances radiation-induced apoptosis in RIE-S cells but not in RIE-AS cells. [1] In the in vitro ovarian perfusion model, NS-398 (10 µM) reduces the number of ovulations initiated by luteinizing hormone (LH) and isobutyl-methylxanthine. NS-398 reduces the synthesis of prostaglandin E2 (PGE2) in isolated, LH-stimulated preovulatory follicles incubated in vitro. [2] NS-398 can reduce the proliferation of monolayer cell cultures, as well as the growth of spheroids and tumor cell migration, in a dose-dependent manner. NS-398 suppresses the proliferation of the two glioma cell lines (NS-398 and U-251MG) with IC50 of 80 and 130 µM, respectively. [3] NS-398 reduces Colo320 and THRC cell lines proliferation with IC50 of 54.8 and 77.2 µM, respectively. [4] NS-398 inhibits hepatocyte growth factor (HGF)-induced invasiveness of HepG2 human hepatoma cells through extracellular signal-regulated kinase (ERK) 1/2. [5] NS-398 inhibits the proliferation and maturation of differentiated myogenic precursor cells. NS-398 promotes fibrosis by upregulating TGF-β1 expression. [6] NS-398 (36 mg/kg) enhances the effect of radiation on H460 tumors in vivo. [1] NS-398 decreases the regeneration of injured muscle by delaying the maturation of regenerating myofibers. NS-398 administration also reduces the inflammatory response and up-regulated myostatin expression. [6]

Protocols

NS-398 is dissolved in DMSO and stored at -20°C. [1]

References

[1] Pyo H, et al. A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res. 2001, 7(10): 2998-3005. 閵嗏偓閵嗏偓
[2] Euchenhofer C, et al. Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat. Neurosci Lett. 1998, 248(1): 25-28. 閵嗏偓閵嗏偓
[3] Joki T, et al. Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res. 2000, 60(17): 4926-4931. 閵嗏偓閵嗏偓
[4] Hara A, et al. Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines. Jpn J Cancer Res. 1997, 88(6): 600-604. 閵嗏偓閵嗏偓
[5] Abiru S, et al. Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. Hepatology. 2002, 35(5): 1117-1124. 閵嗏偓閵嗏偓

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