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KI0663NU10255 mg$190

Chemical Characteristic

Product NameNU1025
CAS No.90417-38-2
Molecular Weight 176.17
FormulaC9H8N2O2
Chemical Structure

Biological activities

NU1025 is a potent poly (ADP-ribose) polymerase (PARP) inhibitor. NU1025 inhibits PARP with an IC50 of 0.4 µM. The recovery from potentially lethal γ-irradiation damage cytotoxicity in plateau-phase cells is also inhibited by NU1025.[1] NU1025 inhibits PARP with a Ki of 50 nM. NU1025 treatment also profoundly reduces colony formation (up to 100 fold) of MCF-7 and MDA-MB- 231 cells when BRCA2 is depleted by RNAi compared with untreated control cells. [2] NU1025 can enhance the cytotoxicity of DNA-methylating agents and ionizing radiation by inhibiting DNA repair. [3]

Protocols

NU1025 is dissolved in DMSO at 100 mM and stored at -20°C. [1]

References

[1] Bowman KJ, et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly (ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer. 1998, 78(10): 1269-1277. 閵嗏偓閵嗏偓
[2] De Soto JA, et al. PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Int J Med Sci. 2006, 3(4): 117-1123. 閵嗏偓閵嗏偓
[3] Bowman KJ, et al. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br J Cancer. 2001, 84(1): 106-112.

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