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KI2514NU905610 mg$325

Chemical Characteristic

Product NameNU9056
SynonymsN/A
CAS No.1450644-28-6
Molecular Weight 232.37
FormulaC6H4N2S4
Chemical Name?5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Smiless1nccc1SSc1sncc1
Chemical Structure

Biological activities

NU9056 is a Tip60 specific inhibitor. NU9056 shows activity against Tip60, p300, PCAF and GCN5 with IC50s of 2, 60, 33 and more than 100 μM, respectively. NU9056 dose-dependently decreases levels of acetylated histone H4K16, H3K14 and H4K8 in LNCaP cells. NU9056 results in both caspase 3 and caspase 9 activation in a time- and concentration-dependent manner. Furthermore, pre-treatment with NU9056 inhibits both ATM phosphorylation and Tip60 stabilization in response to ionising radiation.[1]

Protocols

In vitro, NU9056 is dissolved in DMSO.[1]

References

[1] Coffey K, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012, 7(10): e45539.

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