Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI3430NVP-ADW7424 mg$320

Chemical Characteristic

Product NameNVP-ADW742
CAS No.475488-23-4
Molecular Weight 453.58
FormulaC28H31N5O
Chemical Name5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
Smilesc1nc2c(c(n1)N)c(cn2C1C[C@@H](C1)CN1CCCC1)c1cc(ccc1)OCc1ccccc1
Chemical Structure

Biological activities

NVP-ADW742 is a small molecule ATP-competitive inhibitor of the IGF-I receptor (IGF-IR) with an IC50 of 0.17 µM.[1] NVP-ADW742 inhibits the growth of cells that are highly dependent on IGF-I signaling. NVP-ADW742 inhibits IGF-I signaling with an IC50 of 0.1??.2 µM, which correlated well with an IC50 for IGF-1-mediated growth of 0.2 ??.4 µM.[2] In vitro, NVP-ADW742 inhibits the growth of and induces apoptosis in multiple SCLC cell lines. In SCLC cell lines, NVP-ADW742 also blocks IGF-I-mediated VEGF expression. In the WBA cell line, NVP-ADW742 only partially inhibits Akt activity and enhances cytotoxicity.[1] In the H209 cell lines. NVP-ADW742 enhances both the growth suppressive effects and cytotoxicity of etoposide in a dose-dependent fashion.[2] In vivo, in a mouse model of diffuse multiple myeloma (MM), administration of NVP-ADW742??0 mg/kg twice daily??hows inhibiting tumor growth, prolonging survival and enhancing the antitumor effect of cytotoxic chemotherapy.[3]

Protocols

In vitro, NVP-ADW742 is dissolved in DMSO.[2]

References

[1] Warshamana-Greene GS, et al. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res. 2005, 11(4):1563-1571.
[2] Mitsiades CS, et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell. 2004, 5(3):221-230.
[3] Warshamana-Greene GS, et al. The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol Cancer Ther. 2004, 3(5):527-535.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook