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Cat. No. Name Size Price Add Cart
KI0703Ofloxacin50 mg$154

Chemical Characteristic

Product NameOfloxacin
SynonymsFloxin, Ocuflox
CAS No.82419-36-1
Molecular Weight 361.37
FormulaC18H20FN3O4
Chemical Name(+/-)-9-Fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
SmilesO1CC(n2c3c1c(c(cc3c(=O)c(c2)C(=O)O)F)N1CCN(CC1)C)C
Chemical Structure

Biological activities

Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its??irror image or enantiomer dextrofloxacin. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Ofloxacin inhibits DNA gyrase, a type II topoisomerase, and topoisomerase IV. The MICs of (+)-, (-)-, and (+)-ofloxacin for M. luteus ATCC 4698, as determined by the twofold broth dilution method with 105 CFU/mL, are 200, 0.78, and 1.56 µg/mL, respectively.[1] Ofloxacin inhibits the medium chain acyl-CoA synthetase in a mixed-type manner with Ki value of 38.2 µM.[2] In vitro, ofloxacin also inhibits migration of leukocytes with an IC50 of 0.63 µg/mL.[3] Ofloxacin inhibits all strains of Bacteroides fragilis at a concentration of 3.125 mg/L and the gram-positive anaerobes at 0.5 mg/L. In mice experimentally infected with various gram-positive and gram-negative bacteria, ofloxacin is more active than norfloxacin and pipemidic acid. With the gram-negative pathogens, orally administered ofloxacin is as active as gentamicin used parenterally.[4]

Protocols

In vivo: Ofloxacin is dissolved in saline.[4]

References

[1] Imamura M, et al. Inhibition of DNA gyrase by optically active ofloxacin. Antimicrob Agents Chemother. 1987, 31(2): 325-327.
[2] Kasuya F, et al. Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase. Biochem Pharmacol. 2001, 62(3): 363-367.
[3] Zhou Z, et al. Study on the effect of ofloxacin and tanshinone II A on human leukocyte chemotactic migration in vitro. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1997, 19(3): 232-235.
[4] Seibert G, et al. Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues. Eur J Clin Microbiol. 1983, 2(6): 548-553.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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