Omeprazole Inhibitor CAS No. 73590-58-6

Cat. No.	Name	Size	Price	Add Cart
KI0770	Omeprazole	50 mg	$154

Chemical Characteristic

Product Name	Omeprazole
Synonyms	Prilosec
CAS No.	73590-58-6
Molecular Weight	345.42
Formula	C₁₇H₁₉N₃O₃S
Chemical Structure

Biological activities

Omeprazole is a proton pump inhibitor. The IC50 of omeprazole is 12 nM against the proton pump.^[1] Omeprazole blocks gastric acid secretion by specific inhibition of gastric parietal cell membrane H⁺-K⁺-ATPase. Omeprazole inhibits PGE_{2- and PTH-stimulated Ca²⁺ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.^[2] Omeprazole generates a time- and concentration-dependent increase in a cytochrome P450IA2 accumulation.^[3] Omeprazole competitively inhibits the H. pylori urease enzyme.^[4] Acid-activated omeprazole inhibits lysophosphatide acyltransferase (LAT) in a concentration-dependent manner. Omeprazole inhibits spontaneous PGI2 release in a concentration-dependent manner with an IC50 of 14.3 µM.^[5]}

Protocols

In vitro: Omeprazole is dissolved in polyethylene glycol 400(PEG) pH 2.^[5]

References

[1] Bastaki SM, et al. Comparison of five antisecretory agents acting via gastric H+/K⁺-ATPase. J Physiol Paris. 2000, 94(1): 19-23. 閵嗏偓閵嗏偓 [2] Tuukkanen J, et al. Omeprazole, a specific inhibitor of H+-K⁺-ATPase, inhibits bone resorption in vitro. Calcif Tissue Int. 1986, 38(2): 123-125. 閵嗏偓閵嗏偓 [3] Diaz D, et al. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology. 1990, 99(3): 737-747. 閵嗏偓閵嗏偓 [4] Jensen JC, et al. Inhibition of human liver cytochrome P-450 by omeprazole. Br J Clin Pharmacol. 1986, 21(3): 328-330. 閵嗏偓閵嗏偓 [5] Hell M, et al. Effect of omeprazole on eicosanoid formation in and release from guinea-pig gastric mucosal cells. Br J Pharmacol. 1987, 91(1): 69-75. 閵嗏偓閵嗏偓

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