Ostarine Inhibitor CAS No. 841205-47-8

Cat. No.	Name	Size	Price
KI0132	Ostarine	5 mg	$272
	Ostarine	10 mg	$512
	Ostarine	50 mg	$1552
	Ostarine	200 mg	$3952

Chemical Characteristic

Product Name	Ostarine
Synonyms	GTx-024, MK-2866, Enobosarm, S-22
CAS No.	841205-47-8
Molecular Weight	389.33
Formula	C₁₉H₁₄F₃N₃O₃
Chemical Name	(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
Smiles	C(=O)([C@@](COc1ccc(cc1)C#N)(C)O)Nc1cc(c(cc1)C#N)C(F)(F)F
Chemical Structure
Documents	COA HPLC MS

Biological activities

Ostarine is a selective androgen receptor modulator (SARM) with K_{i of 3.8 nM. Plasma concentration of ostarine declines in a biexponential manner after intravenous administration with terminal half-live of 6.0 hours. In vivo, ostarine significantly stimulates the growth of prostate, seminal vesicles, and levator ani muscle in castrated rats. Ostarine restores the weights of the prostate to 39.2%, of that observed in the intact control. The weight of seminal vesicle is also restored by ostarine to 78.8%, respectively, of that observed in the intact control. Ostarine stimulates the growth of levator ani muscle to a greater extent than androgenic organs, to 141.9%. Nonlinear regression analysis of dose-response relationships for ostarine shows that the ED50 values are 0.12, 0.39, and 0.03 mg/day in prostate, seminal vesicles, and levator ani muscle, respectively. Ostarine maximally restores the weights of prostate, seminal vesicles, and levator ani muscle to 51.1, 98.0, and 136.3, respectively, of that the intact control. Ostarine exerts efficacious and selective activity in anabolic tissues at dose rates as low as 0.03 mg/day, indicative of the high potency of ostarine in anabolic tissue. Ostarine demonstrates the greatest in vivo androgenic and anabolic activity of any androgen receptor (AR) nonsteroidal agonist examined to date and exceeds the anabolic activity of testosterone propionate (TP). ^[1]}

Protocols

Ostarine is dissolved in DMSO. ^[1]

References

[1] Kim J, et al. The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4- nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators. J Pharmacol Exp Ther. 2005, 315(1): 230-239.

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