Oxandrolone Inhibitor CAS No. 53-39-4

Cat. No.	Name	Size	Price	Add Cart
KI0695	Oxandrolone	1 mg	$330

Chemical Characteristic

Product Name	Oxandrolone
Synonyms	Oxandrin, Anavar
CAS No.	53-39-4
Molecular Weight	306.44
Formula	C₁₉H₃₀O₃
Chemical Structure
Documents	MS

Biological activities

Oxandrolone is an oral anabolic steroid. Oxandrolone inhibits β-glucuronidase activity with an IC50 of 190.3 µM. Oxandrolone can promote muscle re-growth in AIDS for the treatment of severe burn injury, trauma, chronic infections, neuromuscular disorders and alcoholic hepatitis.^[1] The use of high-dose oxandrolone results in increased nuclear fluorescence of the osteoblast AR, increased osteoblast differentiation markers in cultured osteoblasts and decreased bone marker in cultured osteocyte-like cells in vitro. ^[2] Oxandrolone suppresses glucocorticoid action via crosstalk between androgen receptor (AR) and glucocorticoid receptor (GR). In cells expressing the GR without the AR, oxandrolone alone (5 µM) causes a negligible increase in luciferase activity. Oxandrolone markedly depresses luciferase expression induced by both methylprednisolone and dexamethasone. Oxandrolone induces essentially complete migration of AR to the nucleus. ^[3] Oxandrolone administration significantly increases mRNA concentrations of skeletal muscle AR without changing insulin-like growth factor I mRNA concentrations. Short term oxandrolone administration stimulates an increase in skeletal muscle protein synthesis and improves intracellular reutilization of amino acids. ^[4]

Protocols

Oxandrolone (2.5 mg) is diluted in 2 mL of DMSO and subsequently diluted in culture media. ^[2]

References

[1] Choudhary MI, et al. New oxandrolone derivatives by biotransformation using Rhizopus stolonifer. Steroids. 2009, 74(13-14): 1040-1044. 閵嗏偓閵嗏偓 [2] Bi LX, et al. The effect of oxandrolone treatment on human osteoblastic cells. J Burns Wounds. 2007, 6: e4. 閵嗏偓閵嗏偓 [3] Zhao J, et al. Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids. 2004, 69(5): 357-366. 閵嗏偓閵嗏偓 [4] Sheffield-Moore M, et al. Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. J Clin Endocrinol Metab. 1999, 84(8): 2705-2711. 閵嗏偓閵嗏偓

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