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Cat. No. Name Size Price Add Cart
KI1000Pamidronate Disodium50 mg$154

Chemical Characteristic

Product NamePamidronate Disodium
SynonymsPamidronic acid
CAS No.57248-88-1
Molecular Weight 279.03
FormulaC3H9NNa2O7P2
Chemical Name3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt
Smiles[Na] [Na] C(CCN)(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure

Biological activities

Pamidronate disodium is an important class of drug for the treatment of bone diseases. Pamidronate disodium inhibits bone resorption by suppressing the action of osteoclasts through antagonizing the mevalonate pathway, thereby reducing osteolytic bone metastases derived from different cancers, i.e. breast carcinoma and multiple myeloma.[1] Pamidronate disodium treatment provokes a significant increase in the [Ca2+] parallel to the enhancement in NO release, while the myeloperoxidase activity is significantly reduced.[2] In seven osteosarcoma cell lines (HOS, MG-63, OST, SaOS-2, SJSA-1, U2OS and ZK-58), pamidronate disodium inhibits cell growth in a time- and dose-dependent manner, and decreases proliferation for up to 73% at 50 µM after 72 hours.[1] Pamidronate disodium (ranging from 100 to 1000 µM) significantly decreases the viability of osteosarcoma cells in a concentration- and time-dependent manner, most consistently after 48 and 72 hours' exposure.[3]

Protocols

In vitro: Pamidronate disodium is dissolved in sterile phosphate buffer.[4]

References

[1] Sonnemann J, et al. The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro. Anticancer Drugs. 2001, 12(5): 459-465.
[2] Salvolini E, et al. The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: an in vitro study. Cell Mol Biol Lett. 2009,14(3): 457-465.
[3] Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs. Am J Vet Res. 2005, 66(5): 885-891.
[4] Urbina JA, et al. Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs. J Biol Chem. 1999, 274(47): 33609-33615.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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