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Cat. No. Name Size Price Add Cart
KI2372PD17395525 mg$1482

Chemical Characteristic

Product NamePD173955
SynonymsN/A
CAS No.260415-63-2
Molecular Weight 443.35
FormulaC21H16Cl2N4OS
Chemical Name6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
Smilesc1(nc2c(cn1)cc(c(=O)n2C)c1c(cccc1Cl)Cl)Nc1cc(ccc1)SC
Chemical Structure

Biological activities

PD173955 is a Src family-specific tyrosine kinase inhibitor. PD173955 is also an Abl inhibitor.[1] PD173955 inhibits cSrc with an IC50 of 20 nM.[2] PD173955 inhibits Abl with an IC50 of 5 nM. PD173955 is also a potent inhibitor of Kit ligand-dependent cell proliferation through inhibition of the receptor tyrosine kinase c-Kit with an IC50 of 50 nM. In vitro, PD173955 is effective at shutting down the kinase activity of Bcr-Abl with an IC50 of 1-2 nM.[1]

Protocols

In vitro, PD173955 is dissolved in DMSO.[1]

References

[1] Nagar B, et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 2002, 62(15): 4236-4243.
[2] Cruzalegui F. Targeting Src family kinases for anticancer therapy[J].

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Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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