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Cat. No. Name Size Price Add Cart
KI2088PF-0497172910 mg$728
PF-0497172925 mg$1300
PF-0497172950 mg$2210

Chemical Characteristic

Product NamePF-04971729
SynonymsPF04971729, PF 04971729
CAS No.1210344-57-2
Molecular Weight 436.9
FormulaC22H25ClO7
Chemical Name(1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
SmilesC1[C@@]2([C@H]([C@@H]([C@H]([C@](O1)(O2)c1cc(c(cc1)Cl)Cc1ccc(cc1)OCC)O)O)O)CO
Chemical Structure

Biological activities

PF-04971729 is an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). Plasma clearances of PF-04971729 in rats and dogs are 4.04 and 1.64 mL·min-1·kg-1, respectively, which results in the half-lives of PF-04971729 in rats and dogs of 4.10 and 7.63 hours, respectively. In addition, it weakly inhibits the organic cation transporter 2-mediated uptake of [14C]metformin with an IC50 of ??00 μM.[1]

References

[1] Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011, 39(9): 1609-1619.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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