Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0907Pimecrolimus10 mg$176

Chemical Characteristic

Product NamePimecrolimus
SynonymsElidel, ASM 981
CAS No.137071-32-0
Molecular Weight 810.45
FormulaC43H68ClNO11
Chemical Structure

Biological activities

Pimecrolimus is a cell-selective inhibitor of inflammatory cytokines. Pimecrolimus has been specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, and plaque-type psoriasis. Pimecrolimus inhibits the production of inflammatory cytokines in T cells and mast cells and prevents the release of preformed inflammatory mediators from mast cells. Pimecrolimus inhibits the growth of 3 different cell lines (the human keratinocyte line HaCaT, the melanoma cell line G361 and the umbilical vein endothelial line ECV-304) with IC50 range from 3.5 to 7 µM.[1] Pimecrolimus inhibits Th1 cytokine synthesis and also prevents the up-regulation of the OX40 co-receptor on primed T cells. Pimecrolimus inhibits the up-regulation of CD134, CD25 and CD54 expression with IC50 of 10, 1 and 0.1 nM, respectively. Pimecrolimus also inhibits T cell proliferation stimulated by allogeneic DC with an IC50 of 0.55 nM.[2] Pimecrolimus effectively reduces skin inflammation and pruritus in hypomagnesemic hairless rats.[1]

References

[1] Stuetz A, et al. Pimecrolimus (Elidel, SDZ ASM 981)- preclinical pharmacologic profile and skin selectivity. Semin Cutan Med Surg. 2001, 20(4): 233-241. 閵嗏偓閵嗏偓
[2] Kalthoff FS, et al. Pimecrolimus inhibits up-regulation of OX40 and synthesis of inflammatory cytokines upon secondary T cell activation by allogeneic dendritic cells. Clin Exp Immunol. 2002, 130(1): 85-92. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook