Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI1106Pizotifen malate50 mg$154

Chemical Characteristic

Product NamePizotifen malate
CAS No.5189-11-7
Molecular Weight 429.53
FormulaC23H27NO5S
Chemical Name4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine;2-hydroxybutanedioic acid
SmilesN1(CCC(=C2c3ccsc3CCc3c2cccc3)CC1)C C(=O)(C(CC(=O)O)O)O
Chemical Structure

Biological activities

Pizotifen malate is an antihistamine and serotonin inhibitor. Pizotifenmalate is a potent antagonist of 5-HT2 and histamine H1 receptors used prophylaxis for migraine headaches.[1] The bioavailability of oral pizotifen malate is 78%, with a plasma protein binding of 91% and an elimination half-life of 23 hour.[2] In striatal HdhQ111/Q111 cells, pizotifen malate treatment causes transient ERK activation and significantly blocks caspase activation in a dose-depend manner. In the R6/2 HD mouse model, treatment with pizotifen malate (7.5 and 10 mg/kg) activates ERK in the striatum, reduces neurodegeneration and significantly enhances motor performance.[3]

Protocols

In vitro: 2.4 mg/mL pizotifen malate stock solution is prepared in isotonic buffer [NaCl (150mM)-Hepes (20mM), pH 4.6].[2]

References

[1] Solomon GD, et al. Therapeutic advances in migraine. J Clin Pharmacol. 1993, 33(3): 200-209.
[2] Serna-Jim?nez CE, et al. HPLC-UV analytical method for determination of pizotifen after in vitro transdermal diffusion studies. Biomed Chromatogr. 2012, 26(6): 769-774.
[3] Sarantos MR, et al. Pizotifen activates ERK and provides neuroprotection in vitro and in vivo in models of Huntington's disease. Journal of Huntington?? Disease. 2012, 195??10.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook