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Cat. No. Name Size Price Add Cart
KI0665Praziquantel50 mg$154

Chemical Characteristic

Product NamePraziquantel
SynonymsBiltricide, EMBAY 8440, Cesol, Cestoved, Cysticide, Distoside, Droncit, Drontal, D-Worm, Kaicide, Milbemax, Popantel, PraziPro, Profender, Zentozide
CAS No.55268-74-1
Molecular Weight 312.41
FormulaC19H24N2O2
Chemical Structure

Biological activities

Praziquantel is a broad-spectrum anthelmintic active against schistosome species.[1]Praziquantel is also an antiparasitic drug. Praziquantel inhibits binding of [3H] ouabain to intact parasites in a pharmacologic specific manner with an IC50 of 0.9 µM. [2] The IC50 of praziquantel against three adult worms (Caenorhabditis elegans, Paramphistomum epiclitum and Schistosoma mansoni) is 484, 1.96 and 82.57 µg/mL, respectively. [3] Praziquantel can greatly enhance the anticancer efficacy of paclitaxel (PTX) in various cancer cell lines, including PTX-resistant cell lines (DLD-1 and H1299). Praziquantel synergistically enhances PTX-induced cell growth inhibition. The co-treatment of praziquantel and PTX also induce significant mitotic arrest and activate the apoptotic cascade. The cotreatment of praziquantel and PTX can markedly decrease expression of X-linked inhibitor of apoptosis protein (XIAP). Moreover, praziquantel combined with PTX results in a more pronounced inhibition of tumor growth compared with either drug alone in a mouse xenograft model. [4] Single doses of praziquantel at 50 or 100 mg/kg result in killing of all trematodes. [5]

Protocols

Stock solution of praziquantel at 10 mg/mL is prepared with 60% DMSO. [5]

References

[1] Harnett W, et al. Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology. 1986, 93 (Pt 2): 401-405. 閵嗏偓閵嗏偓
[2] Fetterer RH, et al. Characterization and localization of ouabain receptors in Schistosoma mansoni. Molecular and Biochemical Parasitology. 1980, 1(4): 209-219. 閵嗏偓閵嗏偓
[3] Atjanasuppat K, et al. In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand. J Ethnopharmacol. 2009, 123(3): 475-482. 閵嗏偓閵嗏偓
[4] Redman CA, et al. Praziquantel: an urgent and exciting challenge. Parasitol Today. 1996, 12(1): 14-20. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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