Pregabalin Inhibitor CAS No. 148553-50-8

Cat. No.	Name	Size	Price	Add Cart
KI1354	Pregabalin	100 mg	$2560

Chemical Characteristic

Product Name	Pregabalin
Synonyms	Lyrica
CAS No.	148553-50-8
Molecular Weight	159.23
Formula	C₈H₁₇NO₂
Chemical Name	3-(Aminomethyl)-5-methyl-hexanoic acid
Smiles	C(=O)(CC(CC(C)C)CN)O
Chemical Structure

Biological activities

Pregabalin is an anticonvulsant drug used for treating a variety of disorders, including partial seizures, neuropathic pain, generalized anxiety disorder, and fibromyalgia. Pregabalin competively binds to the α2δ (alpha2delta) subunit-1 and α2δ (alpha2delta) subunit-2 of the voltage-dependent calcium channel with IC50 values of 52 and 55 nM, respectively. Pregabalin, at the concentrations up to 100 µM, does not displace radioligands from 38 widely studied receptor sites including adenosine A, α-adrenoceptor, β-adrenoceptor, histamine H_{1, and muscarinic M.^[1] Pregabalin decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide.^[2] Pregabalin produces concentration-dependent inhibitions of the K(+)-induced [Ca⁽²⁺⁾]_{(i) increases in fura-2-loaded human neocortical synaptosomes with an IC50 of 17 µM.^[3] Intravenous injection of 10-30 mg/kg pregabalin in vivo dose-dependently attenuates tactile allodyniaand thermal hyperalgesia. Furthermore, intravenous injection of pregabalin (30 mg/kg) significantly inhibits the ectopic discharges from injured afferents in a dose-dependent manner.^[4]}}

Protocols

In vivo: Pregabalin is dissolved in sterile saline.^[4]

References

[1] Li Z, et al. Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits. Eur J Pharmacol. 2011, 667(1-3): 80-90. [2] Micheva KD, et al. Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006, 70(2): 467-476. [3] Fink K, et al. Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology. 2002, 42(2): 229-236. [4] Chen SR, et al. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology. 2001, 95(6): 1473-1479.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com