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Cat. No. Name Size Price Add Cart
KI3245PuerarinQuoteQuote

Chemical Characteristic

Product NamePuerarin
CAS No.3681-99-0
Molecular Weight 416.38
FormulaC21H20O9
Chemical Name4H-1-Benzopyran-4-one, 8-?-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-
Smilesc1c(c(=O)c2c(o1)c(c(cc2)O)C1[C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)c1ccc(cc1)O
Chemical Structure

Biological activities

Puerarin is an isoflavone C-glycoside isolated from the root of Pueraria lobata. Puerarin has comprehensive biological actions, regarding the protective effects on hypercholesterolemia, diabetic retinpathy, ischemic myocardial injury, ischemic brain injury, liver fibrosis, osteonecrosis, inflammation, and oxidation.[1] Puerarin has been used as an anti-hyperglycemic agent. Puerarin effectively inhibits the formation of advanced glycation end product (AGE) formation. Puerarin significantly inhibits pericyte apoptosis, the generation of reactive oxygen species (ROS), and NADPH oxidase activity by inhibiting the phosphorylation of p47phox and Rac1.[2] Puerarin dose dependently prevents the onset of endothelial progenitor cells senescence in culture. Puerarin significantly increases telomerase activity and phosphorylation of Akt.[3] Puerarin can also scavenge reactive oxygen species, increase SOD activity, and inhibit protein nonenzymatic glycation. In vitro, puerarin (at 100 mM) significantly decreases the number of vascular smooth muscle cells induced by high glucose inhibition.[4] In vivo, puerarin (120, and 60 mg/kg, i.p.) can reduce infarct area in the heart of rat with myocardial infarction (MI). Puerarin (120 mg/kg) induces angiogenesis in the non-ischemic and ischemic myocardium, which is one of the mechanisms of curing coronary artery diseases.[5]

Protocols

In vitro, puerarin is dissolved in DMSO medium.[4]

References

[1] Zhang W, et al. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur J Pharmacol. 2010, 649(1-3): 398-402.
[2] Kim J, et al. Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. Free Radic Bio Med. 2012, 53(2): 357-365.
[3] Zhu J, et al. Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity. Vascul Pharmacol. 2008, 49(2-3): 106-110.
[4] Zhu LH, et al. Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. Free Radic Biol Med. 2010, 48(4): 471-482.
[5] Zhang S, et al. Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biol Pharm Bull. 2006, 29(5): 945-950.

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