Purmorphamine Inhibitor CAS No. 483367-10-8

Cat. No.	Name	Size	Price	Add Cart
KI3740	Purmorphamine	5 mg	$250
KI3740	Purmorphamine	25 mg	$800

Chemical Characteristic

Product Name	Purmorphamine
CAS No.	483367-10-8
Molecular Weight	520.62
Formula	C₃₁H₃₂N₆O₂
Chemical Name	9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Smiles	n1cn(c2nc(nc(c12)Nc1ccc(cc1)N1CCOCC1)Oc1cccc2ccccc12)C1CCCCC1
Chemical Structure

Biological activities

Purmorphamine, which directly binds to and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 ?M. It also is an inducer of osteoblast differentiation with EC50 of 1 ?M ^[1]. It is a Hedgehog agonist. Purmorphamine directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway. Hedgehog agonist Purmorphamine most significantly increased the neuronal differentiation of a human striatal NSC line (STROC05). Purmorphamine up-regulated gene expression of the mediators of Hh pathway, SMO, PTCH1, GLI1, and GLI2. The activation of Hh pathway by Purmorphamine increased the expression of several genes. Purmorphamine triggers Hh signaling pathway in hMSCs, inducing an increase in the expression of a set of genes involved in the osteoblast differentiation program ^[2]. In vitro, it can be used by 1 ?M in 3T3-L1 cells ^[3].

References

[1] F. Faghihia, M. Baghaban Eslaminejada, A. Nekookara, et al. The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Biomedicine & Pharmacotherapy. 2013, 67(1): 31-38. [2] Gran?li C, Karlsson C, Lindahl A, et al. Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells. Cells Tissues Organs. 2013,197(2):89-102. [3] Gu D, Fan Q, Zhang X, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012,287(45):38356-38366.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com