Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0676Ramipril500 mg$154

Chemical Characteristic

Product NameRamipril
SynonymsAltace
CAS No.87333-19-5
Molecular Weight 416.51
FormulaC23H32N2O5
Chemical Structure

Biological activities

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. Ramipril inhibits the brush border ACE with an IC50 of 3 nM.[1] In vitro, ramipril inhibits the fetal calf serum (FCS)-induced DNA synthesis and cell proliferation in a dose-dependent manner in human mesangial cells. Moreover, ramipril significantly reduces FCS-induced platelet-derived growth factor (PDGF) A and B chain gene expression. Ramipril also can completely abolish the PDGF A and B chain gene expression induced by phorbol 12-myristate 13-acetate, a specific protein kinase C activator.[2] In aortas isolated from rats orally treated with ramipril (1 or 10 mg/kg), the toxic effect of oxidized low-density lipoproteins (LDL) is markedly attenuated.[3] Ramipril treatment inhibits of the tissue renin-angiotensin system in another animal models.[4] Furthermore, aortic segments from rabbits concomitantly treated with ramipril (0.3 and 3.0 mg/kg/day) shows well-preserved relaxation and matching basal cGMP content compared to normal controls in rabbits fed an atherogenic diet (0.25% cholesterol).[5] In ischemic isolated rat hearts, single oral pretreatment with ramipril (1 mg/kg) protects against ventricular fibrillation.[6]

Protocols

In vivo: Ramipril is dissolved in 1 mL 0.9% saline.[6]

References

[1] Stevens BR, et al. Human intestinal brush border angiotensin-converting enzyme activity and its inhibition by antihypertensive Ramipril. Gastroenterology. 1988, 94(4): 942-947.
[2] Grandaliano G, et al. Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999, 7(3): 229-235.
[3] Berkenboom G, et al. Ramipril prevents endothelial dysfunction induced by oxidized low-density lipoproteins: a bradykinin-dependent mechanism. Hypertension. 1997. 30(3 Pt 1): 371-376.
[4] Vasmant D, et al. The renin-angiotensin system and ramipril, a new converting enzyme inhibitor. J Cardiovasc Pharmacol. 1989, 14 Suppl 4: S46-52.
[5] Becker RH, et al. Preservation of endothelial function by ramipril in rabbits on a long-term atherogenic diet. Cardiovasc Pharmacol. 1991, 18 Suppl 2: S110-115.
[6] Linz W, et al. Beneficial effects of the converting enzyme inhibitor, ramipril, in ischemic rat hearts. J Cardiovasc Pharmacol. 1986, 8 Suppl 10: S91-99.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook