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Cat. No. Name Size Price Add Cart
KI0755Reserpine1 g$210

Chemical Characteristic

Product NameReserpine
SynonymsSerpasil, Serpalan
CAS No.50-55-5
Molecular Weight 608.68
FormulaC33H40N2O9
Chemical Structure

Biological activities

Reserpine is an indole alkaloid antipsychotic and antihypertensive drug. Reserpine has been used for the control of high blood pressure and for the relief of psychotic symptom. Reserpine inhibits the accumulation of 3H dopamine (DA) with an IC50 of 8.5 nM.[1] Reserpine inhibits the transport of [3H] serotonin by membranes prepared from COS cells transiently transfected with chromaffin granule amine transporter (CGAT), with an IC50 of 100 nM. In the same transient expression system, synaptic vesicle amine transporter (SVAT) shows a similar sensitivity to reserpine with an IC50 of 80 nM. Reserpine inhibits vesicular amine transport, depleting monoamine stores and reducing blood pressure.[2] Pre-treatment with 10.0 mg/kg reserpine (18 hours prior to AMPH or MDMA) attenuates dopamine release for high and low D-amphetamine (AMPH) doses. Pre-treatment with 10.0 mg/kg reserpine attenuates dopamine and serotonin release induced by methylenedioxymethamphetamine (MDMA). [3] Repeated reserpine (2 mg/kg i.p.) significantly decreases the concentration of [18F] GBR 13119 in the mouse striatum. [4]

Protocols

Reserpine is dissolved in a vehicle consisting of a glacial acetic acid (3%)閳ユ徏lucose solution. [3]

References

[1] Ary TE, et al. Phencyclidine: effect on the accumulation of 3H-dopamine in synaptic vesicles. Life Sci. 1980, 26(7): 575-578. 閵嗏偓閵嗏偓
[2] Peter D, et al. The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. J Biol Chem. 1994, 269(10): 7231-7237. 閵嗏偓閵嗏偓
[3] Sabol KE, et al. Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis. Brain Res. 1998, 806(1): 69-78. 閵嗏偓閵嗏偓
[4] Kilbourn MR, et al. Repeated reserpine administration reduces in vivo [18F] GBR 13119 binding to the dopamine uptake site. Eur J Pharmacol. 1992, 216(1): 109-112. 閵嗏偓

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