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Cat. No. Name Size Price Add Cart
KI1012Resveratrol1 g$992
Resveratrol5 g$4050

Chemical Characteristic

Product NameResveratrol
Synonyms(E)-5-(4-Hydroxystyryl)benzene-1,3-diol
CAS No.501-36-0
Molecular Weight 228.24
FormulaC14H12O3
Chemical Name3,4',5-Trihydroxy-trans-stilbene
SmilesC(=C\c1cc(cc(c1)O)O)/c1ccc(cc1)O
Chemical Structure

Biological activities

Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Resveratrol slightly suppresses ethoxyresorufin O-deethylation (EROD) activity in human liver microsomes with an IC50 of 1.1 mM. In a human P450 1A1/reductase bicistronic expression system, resveratrol inhibits human P450 1A1 activity in a mixed-type inhibition with Ki of 9 and 89 nM, for competitive and noncompetitive suppression with Ki of 9 and 89 µM, respectively. [1] Resveratrol dose-dependently inhibits the growth of estrogen receptor(ER)-positive MCF-7 cells. Resveratrol antagonizes the growth-promoting effect of 17-β-estradiol (E2) in a dose-dependent fashion at both the cellular (cell growth) and the molecular (gene activation) levels. At 50 µM, resveratrol abolishes the growth-stimulatory effect mediated by concentrations of E2 up to 1 nM in MCF-7 cells. [2] In another study, resveratrol increases the lipid fluidity of synaptosomal plasma membranes.[3] Resveratrol protects mice against diet-induced-obesity and insulin resistance.[4]

Protocols

In vitro Resveratrol is dissolved in DMSO and diluted in PBS.[4]

References

[1] Chun YJ, et al. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem Biophys Res Commun. 1999, 262(1): 20-24.
[2] Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999, 179(3): 297-304.
[3] Fotiou S, et al. Resveratrol activation of nitric oxide synthase in rabbit brain synaptosomes: singlet oxygen (1O2) formation as a causative factor of neurotoxicity.In Vivo. 2010, 24(1): 49-53.
[4] Lagouge M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006, 127(6): 1109-1122.

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