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Cat. No. Name Size Price Add Cart
KI2259RGFP96610 mg$236
RGFP96650 mg$912

Chemical Characteristic

Product NameRGFP966
SynonymsN/A
CAS No.1396841-57-8
Molecular Weight 362.4
FormulaC21H19FN4O
Chemical Name2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)-
SmilesC(=O)(/C=C/c1cnn(c1)C/C=C/c1ccccc1)Nc1c(cc(cc1)F)N
Chemical Structure

Biological activities

RGFP966 is a potent HDAC3 inhibitor with an IC50 of 80 nM. RGFP966 at concentrations up to 15 μM have no effective inhibition of any other HDAC.[1] In vitro, RGFP966 treatment increases apoptosis that is associated with DNA damage and impaires S phase progression, resulting in decreased cell growth in cutaneous T cell lymphoma (CTCL) cell lines.[2] In vivo in mice, systemic treatment with RGFP966 enhances extinction of cocaine-seeking behavior in a persistent manner.[1]

References

[1] Malvaez M, et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013, 110(7): 2647-2652.
[2] Wells CE, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One. 2013, 8(7): e68915.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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