RIFADIN Inhibitor CAS No. 13292-46-1

Cat. No.	Name	Size	Price	Add Cart
KI1386	RIFADIN	1 g	$100

Chemical Characteristic

Product Name	RIFADIN
Synonyms	Rifampin, rifampicin
CAS No.	13292-46-1
Molecular Weight	822.94
Formula	C₄₃H₅₈N₄O₁₂
Chemical Name	3-?[[(4-?methyl-?1-?piperazinyl)?imino]?methyl]?-rifamycin
Smiles	c1(c2c3c4c(c1O)c(c(c(c4O)/C=N/N1CCN(CC1)C)NC(=O)/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]([C@H](/C=C/O[C@@](O2)(C3=O)C)OC)C)OC(=O)C)C)O)C)O)C)/C)O)C
Chemical Structure

Biological activities

Rifadin is a semisynthetic antibiotic produced from Streptomyces mediterranei for treatment of tuberculosis and inactive meningitis. Rifadin has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. The MIC and MBC of rifadin is 0.03 and 0.25 ng/mL, respectively. In susceptible organisms, rifadin inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme, suppressing the initiation of RNA synthesis.^[1] MICs for 50% and 90% of rifadin are 0.1 and >100 µg/mL in M. tuberculosis. MICs for 50% and 90% of rifadin are 6.25 and 50 µg/mL in M. intracellulare.^[2] In OF1 male mice infected with F. solani (FMR 439), rifadin (20 mg/kg/day given once a day by gavage) combined with amphotericin B has an median survival time of 13 days compared to 9 days in control.^[3]

Protocols

In vitro: In vivo: Rifadin at 1,000 µg/mL is prepared with sterile distilled water.^[3]

References

[1] Calvori C, et al. Effect of rifamycin on protein synthesis. Nature. 1965, 207(995): 417-418. [2] Haneishi T, et al. Antimycobacterial activities in vitro and in vivo and pharmacokinetics of dihydromycoplanecin A. Antimicrob Agents Chemother. 1988, 32(1): 110-116. [3] Guarro J, et al. In vitro and in vivo experimental activities of antifungal agents against Fusarium solani. Antimicrob Agents Chemother. 1999, 43(5): 1256-1257.

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