Rifaximin Inhibitor CAS No. 80621-81-4

Cat. No.	Name	Size	Price	Add Cart
KI0704	Rifaximin	100 mg	$248

Chemical Characteristic

Product Name	Rifaximin
Synonyms	Xifaxan, Xifaxanta
CAS No.	80621-81-4
Molecular Weight	785.88
Formula	C₄₃H₅₁N₃O₁₁
Chemical Structure

Biological activities

Rifaximin is a semisynthetic antibiotic. Rifaximin is a poorly absorbed rifamycin derivative. Rifaximin interferes with transcription by binding to the β-subunit of bacterial RNA polymerase. Rifaximin has a broad antimicrobial spectrum that includes gram-positive and gram-negative aerobic and anaerobic bacteria.^[1] The MIC50, MIC90, range, and geometric mean MIC of rifaximin against 110 toxigenic C. difficile isolates is 7.5 ng/mL, 15 ng/mL, 3.8 ng/mL-閿?6 µg/mL, and 9 ng/mL, respectively.^[2] The MIC of rifaximin against 84 diarrheagenic Escherichia coli and 11 Shigella sonnei causing traveler's diarrhea ranges between <0.007 and 32 mg/L.^[3] In vitro against microaerophilic and anaerobic bacteria, rifaximin is much more effective than neomycin.^[4] Rifaximin administration (30 or 50 mg/kg/day) increases survival rates of colitic mice and reduces colitis severity in a rodent model of colitis in vivo.^[5]

Protocols

In vitro: Rifaximin is dissolved in methanol and then diluted in 0.1 M phosphate buffer (pH 7.4) plus 0.45% sodium dodecyl sulfate.^[2]

References

[1] Rizzello F, et al. Rifaximin systemic absorption in patients with ulcerative colitis. Eur J Clin Pharmacol. 1998, 54(1): 91-93. 閵嗏偓閵嗏偓 [2] Hecht DW, et al. In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob Agents Chemother. 2007, 51(8): 2716-2719. [3] Ruiz J, et al. In vitro antimicrobial activity of rifaximin against enteropathogens causing traveler's diarrhea. Diagn Microbiol Infect Dis. 2007, 59(4): 473-475. [4] Ripa S, et al. In vitro antibacterial activity of rifaximin against Clostridium difficile, Campylobacter jejunii and Yersinia spp. Drugs Exp Clin Res. 1987, 13(8): 483-488. 閵嗏偓閵嗏偓 [5] Fiorucci S, et al. Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis. Digestion. 2002, 66(4): 246-256.

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