Rocuronium bromide Inhibitor CAS No. 119302-91-9

Product Name	Rocuronium bromide
Synonyms	Org 9426, Zemuron, Esmeron
CAS No.	119302-91-9
Molecular Weight	609.68
Formula	C₃₂H₅₃BrN₂O₄
Chemical Name	1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidinium bromide
Smiles	[N]1(CCCC1)(CC=C)C1C[C@H]2[C@@H]3CC[C@H]4C[C@@H]([C@H](C[C@@]4([C@H]3CC[C@@]2([C@H]1OC(=O)C)C)C)N1CCOCC1)O Br
Chemical Structure

Biological activities

Rocuronium bromide is a bromide salt of rocuronium. Rocuronium is a nondepolarizing muscle relaxant. ^[1] Rocuronium can competitively inhibit the activation of ε- nAChR and γ-nAChR by Ach. The IC50 of rocuronium for ε-nAChR and γ-nAChR is 169.2 and 8.6 µM, respectively. ^[2] Rocuronium has a rapid onset of activity and may be suitable as a component of a rapid-sequence induction of anesthesia.^[1] The IC50 of rocuronium in combination with vecuronium is 0.7 µM for ε-nAChR and 36.3 µM for γ-nAChR, respectively. ^[2] Rocuronium reduces the indirectly elicited twitch tensions in normal diaphragm with an IC50 of 9.84 µM. Subsequent application of rocuronium (0.1 µM) decreases the magnitude of increased twitch tensions to the control level.^[3] In addition, rocuronium causes less direct histamine release than the benzylisoquinolinium-derived NMBDs, such as atracurium and mivacurium. ^[4] Rocuronium blocks neuromuscular transmission with a non- depolarizing pattern in the RC of CAPs induced from the gastrocnemius muscle in cats. ^[5]

Protocols

Rocuronium is dissolved to 1 mM in modified Krebs solution. ^[3]

References

[1] Wright PM, et al. Onset and duration of rocuronium and succinylcholine at the adductor pollicis and laryngeal adductor muscles in anesthetized humans. Anesthesiology. 1994, 81(5): 1110-1115. [2] Zhao XL, et al. Effects of rocuronium and vecuronium alone or in combination on adult and fetal type muscle nicotinic acetylcholine receptors. Chinese Journal of Anesthesiology. 2005. [3] Narimatsu E, et al. Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion. Am J Emerg Med. 2012, 30(6): 901-907. [4] Rose M, et al. Rocuronium: high risk for anaphylaxis? Br J Anaesth. 2001, 86(5): 678-682. [5] Shiraishi H, et al. Fading responses in the evoked EMG after rocuronium in cats. Can J Anaesth. 1992, 39(10): 1099-1104.

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