S.A.S.-500 (sulfasalazine) Inhibitor CAS No. 599-79-1 - S.A.S.-500 (sulfasalazine) Supplier

Product Name	S.A.S.-500 (sulfasalazine)
Synonyms	Sulfasalazine,Azulfidine, Salazopyrin, Sulazine
CAS No.	599-79-1
Molecular Weight	398.39
Formula	C₁₈H₁₄N₄O₅S
Chemical Structure

Biological activities

Sulfasalazine is a sulfa agent. Sulfasalazine is used specifically to treat rheumatoid arthritis. In an isolated preparation of rat peritoneal cells, sulfasalazine inhibits calcium ionophore-stimulated formation of contractile leukotriene activity with an IC50 of 0.15 mM.^[1] Sulfasalazine inhibits the enzyme activity of thiopurine S-methyltransferase in a noncompetitive manner.^[2] Sulfasalazine prevents the synthesis of 5-lipoxygenase products in a concentration-dependent manner. Sulfasalazine suppresses the synthesis of thromboxane B2 and hydroxyheptadecatrienoic acid in human platelet suspensions after arachidonic acid stimulation. ^[3] Sulfasalazine inhibits the incorporation of arachidonic acid into phospholipids and triglycerides. Sulfasalazine prevents the release of ¹⁴C-AA from membrane phospholipids in a dose-dependent manner.^[4] Sulfasalazine increases the exudate adenosine concentration from 127 to 869 nM. Sulfasalazine enhances adenosine release at an inflamed site.^[5] Sulfasalazine suppresses growth of tumor in female CB-17 scid mice and nude mice xenografted with human gliomas.^[6]

Protocols

In vivo: Sulfasalazine is dissolved in saline.^[5]

References

[1] Nielsen ST, et al. Sulfasalazine and 5-aminosalicylic acid inhibit contractile leukotriene formation. Scand J Gastroenterol. 1988, 23(3): 272-276. 閵嗏偓閵嗏偓 [2] Shipkova M, et al. Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine. Clin Chem. 2004, 50(2): 438-441. 閵嗏偓閵嗏偓 [3] Tornhamre S, et al. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. Eur J Pharmacol. 1989, 169(2-3): 225-234. 閵嗏偓閵嗏偓 [4] Allgayer H, et al. A comparison of effects of sulfasalazine and its metabolites on the metabolism of endogenous vs. exogenous arachidonic acid. Immunopharmacology. 1988, 15(1): 39-46. 閵嗏偓閵嗏偓 [5] Gadangi P, et al. The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 1996, 156(5): 1937-1941. 閵嗏偓閵嗏偓 [6] Chung WJ, et al. Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci. 2005, 25(31): 7101-7110. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.