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Cat. No. Name Size Price Add Cart
KI2531SB70637510 mg$439.4
SB70637550 mg$2051.4

Chemical Characteristic

Product NameSB706375
SynonymsN/A
CAS No.733734-61-7
Molecular Weight 539.36
FormulaC20H22BrF3N2O5S
Chemical Name2-Bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
Smilesc1(c(cc(c(c1)OC)OC)Br)S(=O)(=O)Nc1cc(c(cc1)C(F)(F)F)OC1CN(CC1)C
Chemical Structure

Biological activities

SB706375 is a potent, reversible and selective mammalian UT receptor antagonist. SB706375 inhibits [125I] human urotensin II (hUII) binding to the UT receptor in SJRH30 cells, with a Ki of 5.4 nM. SB706375 also inhibits [125I] human urotensin II (hUII) binding to the rodent, feline, and primate recombinant UT receptors, with Ki values ranging from 4.7 to 20.7 nM.[1] SB706375 is a selective antagonist against both hUT2R and rUT2R, with Kd values of 9 and 21 nM, respectively.[2] SB706375 exhibits high-affinity cross-species antagonism, serving as a useful agent in delineating the pathophysiological actions of urotensin II in mammals.[1]

Protocols

In vitro, SB706375 is dissolved in DMSO.[1]

References

[1] Douglas SA, et al. Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br J Pharmacol. 2005, 145(5): 620-635.
[2] Kim SK, et al. Prediction of the three-dimensional structure for the rat urotensin II receptor, and comparison of the antagonist binding sites and binding selectivity between human and rat receptors from atomistic simulations. ChemMedChem. 2010, 5(9): 1594-1608.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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