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Cat. No. Name Size Price Add Cart
KI2030SCH 5637055 mg$686.4
SCH 56370510 mg$943.8
SCH 56370550 mg$2745.6
SCH 563705200 mg$6292

Chemical Characteristic

Product NameSCH 563705
SynonymsN/A
CAS No.473728-58-4
Molecular Weight 425.48
FormulaC23H27N3O5
Chemical Name3-((3-((dimethylamino)carbonyl)-2-hydroxyphenyl)amino)-4-(((r)-1-(4-isopropylfuran-2-yl)propyl)amino)cyclobut-3-ene-1,2-dione
SmilesC1(=O)C(=O)C(=C1NC(CC)c1occ(c1)C(C)C)Nc1c(c(ccc1)C(=O)N(C)C)O
Chemical Structure

Biological activities

SCH 563705 is a potent CXCR2 and CXCR1 antagonist with Ki values of 1 and 3 nM, respectively. SCH 563705 inhibits chemokine binding to human CXCR2 and CXCR1 with IC50s of 1.3 and 7.3 nM, respectively. SCH 563705 also inhibits both Gro-alpha and IL-8 induced human polymorphonuclear leukocytes (hPMN) migration in vitro.[1] SCH 563705 selectively reduces the peripheral blood neutrophil frequency, and increases the CXCR2 ligand CXCL1.[2] In addition, SCH 563705 has good oral pharmacokinetic profiles in rat, mouse, monkey, and dog.[1]

Protocols

In vivo: SCH 563705 is dissolved in the vehicle 0.4% hydroxypropyl methyl cellulose (MC).[2]

References

[1] Chao J, et al. C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists. Bioorg Med Chem Lett. 2007, 17(13): 3778-3783.
[2] Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis. Biochem Biophys Res Commun. 2010, 391(1): 1080-1086.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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