Silibinin Inhibitor CAS No. 22888-70-6

Cat. No.	Name	Size	Price	Add Cart
KI3641	Silibinin	50 mg	$154

Chemical Characteristic

Product Name	Silibinin
CAS No.	22888-70-6
Molecular Weight	482.43
Formula	C₂₅H₂₂O₁₀
Chemical Name	2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin
Smiles	O1[C@H]([C@H](Cc2c1ccc(c2)C1[C@H](C(=O)c2c(O1)cc(cc2O)O)O)c1cc(c(cc1)O)OC)CO
Chemical Structure
Documents	MSDS MS

Biological activities

Silibinin is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio.^[1] Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.^[2] Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. In vitro, silibinin can be used by 25-200?M in ARPE-19 cells ^[3].

References

[1] Davis-Searles P, Davis-Searles, Yuka Nakanishi, et al. Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells. Cancer Research. 2005,65 (10):4448-4457. [2] Al-Anati L, Essid E, Reinehr R, et al. Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells. Molecular Nutrition & Food Research. 2009, 53 (4): 460??66. [3] Chen YH, Chen CL, Liang CM, et al. Silibinin Inhibits ICAM-1 Expression via Regulation of N-Linked and O-Linked Glycosylation in ARPE-19 Cells. Biomed Res Int. 2014;2014:701395.

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