Sodium butyrate Inhibitor CAS No. 156-54-7

Cat. No.	Name	Size	Price	Add Cart
KI0788	Sodium butyrate	1 g	$80

Chemical Characteristic

Product Name	Sodium butyrate
CAS No.	156-54-7
Molecular Weight	110.09
Formula	C₄H₇NaO₂
Chemical Structure

Biological activities

Sodium butyrate is a histone deacetylase (HDAC) inhibitor. Sodium butyrate has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression.^[1] In HeLa cells, sodium butyrate treatment (5 mM) greatly increases the level of histone acetylation as compared to control cells.^[2] In vitro, permanently differentiated cell populations emerges in a colonic cancer cell line HT29 after sodium butyrate treatment (5 mM).^[3] In vivo, injections of sodium butyrate completely restores contextual memory in the mutant mice.^[4] Sodium butyrate (at already very low concentrations of 0.1 mM) has a considerable treatment effect on microtumours on the chicken egg. In a prostate cancer cell lines (PC3 and TSU-Pr1) xenograft model using nude mice, sodium butyrate treatment inhibits tumor growth through activiting p21/Rb/c-myc-dependent pathway.^[5] In vivo, sodium butyrate treatment also enhances the development of colonic neoplasia and is associated with increased fecal butyric acid concentrations.^[6]

Protocols

In vivo: Sodium butyrate is dissolved in water.^[6]

References

[1] Jacques Kruh, et al. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Molecular and Cellular Biochemistry.1981, 42(2): 65-82 [2] HauRiggs MG, et al. n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells. Nature. 1977, 268(5619): 462-464. [3] Augeron C, et al. Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate. Cancer Res. 1984, 44(9): 3961-3969. [4] Kilgore M, et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2010, 35(4): 870-880. 閵嗏偓閵嗏偓 [5] Kuefer R, et al. Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer. Br J Cancer. 2004, 90(2): 535-541. [6] Freeman HJ, et al. Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rat intestinal neoplasia. Gastroenterology. 1986, 91(3): 596-602. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.