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Cat. No. Name Size Price Add Cart
KI0789Sodium orthovanadate5 g$38

Chemical Characteristic

Product NameSodium orthovanadate
SynonymsSodium vanadate, sodium vanadium oxide
CAS No.13721-39-6
Molecular Weight 183.9
FormulaNa3O4V
Chemical Structure

Biological activities

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. Orthovanadate inhibits the transport of dinitrophenyl-S-glutathione with an IC50 of 80 µM in human erythrocytes.[1] In transient forebrain ischemia, sodium orthovanadate as well as insulinlike growth factor-1 (IGF-1) rescues cells from delayed neuronal death in the hippocampal CA1 region.[2] Sodium orthovanadate at dosages of 10, 100 and 1000 µM can suppress the activity of alpha-glucosidase in the small intestine of normal rats, with an inhibition rate of 68.18%, 87.22% and 91.91%, respectively. Sodium orthovanadate reduces mRNA expression of alpha-glucosidase and GLUT2 in epithelial cells of small intestine.[3] In rats, a single injection of 50 mM sodium orthovanadate at 0 and 45 minutes post-middle cerebral artery occlusion (MCAO) produces similar neuroprotective effects. Furthermore, sodium orthovanadate treatment ameliorates ischemic neuronal cell injury via the activation of both protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) in rats. Sodium orthovanadate also inhibits serum glucose and elicits the gradual recovery of regional cerebral blood flow (rCBF) after transient MCAO in rats. [4]

Protocols

In vivo: Sodium orthovanadate is dissolved in PBS.[2]

References

[1] Pu?aski L, et al. Effect of inhibitors on the transport of dinitrophenyl-S-glutathione in human erythrocytes. Biochem Mol Biol Int. 1995, 36(5): 935-942.
[2] Ai J, et al. Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms. World J Gastroenterol. 2004, 10(24): 3612-3615. 閵嗏偓閵嗏偓
[3] Hasegawa Y, et al. Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J Pharmacol Exp Ther. 2006, 317(2): 875-881.
[4] Kawano T, et al. Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus. J Cereb Blood Flow Metab. 2001, 21(11): 1268-1280. 閵嗏偓閵嗏偓

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