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Cat. No. Name Size Price Add Cart
KI0790Streptozocin1 g$340

Chemical Characteristic

Product NameStreptozocin
SynonymsStreptozotocin, STZ, Zanosar
CAS No.18883-66-4
Molecular Weight 265.22
FormulaC8H15N3O7
Chemical Structure

Biological activities

Streptozocin is an antibiotic produced by a strain of Streptomyces achromogenes. Streptozocin is used in medical research to produce an animal model for Type 1 diabetes in large dose as well as Type 2 diabetes with multiple low doses. The cytotoxic action of streptozocin is mediated by reactive oxygen species. Streptozocin enters the B cell via a glucose transporter (GLUT2) and causes alkylation of DNA.[1] In isolated rat islets of Langerhans in vitro, streptozocin inhibits proinsulin synthesis, as well as insulin release, in a time and concentration dependent manner.[2] Streptozocin exposure also induces a dose-dependent DNA repair synthesis in mouse pancreatic islets in vitro.[3] When streptozocin is administered to rats by i.v. injection, DNA is methylated with the formation of 7-methylguanine, O6-methylguanine, 3-methyladenine, and 7-methyladenine in liver, kidney, intestine, and pancreas.[4] Streptozocin can modulates human lymphocyte O6-alkylguanine-DNA alkyltransferase in vivo.[5] Furthermore, blood glucose levels in the streptozocin-treatment rats are significantly higher than those in the control rats.[6]

Protocols

In vivo: Streptozocin is dissolved in citrate buffer.[6]

References

[1] Szkudelski T, et al. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001, 50(6): 537-546.
[2] Maldonato A, et al. Effects of streptozotocin in vitro on proinsulin biosynthesis, insulin release and ATP content of isolated rat islets of Langerhans. Diabetologia. 1976,12(5): 471-481. 閵嗏偓閵嗏偓
[3] Sandler S, et al. Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro. Diabetologia. 1983, 25(5): 444-447.
[4] Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981, 41(7): 2786-2790. 閵嗏偓閵嗏偓
[5] Gerson SL, et al. Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo. Cancer Res. 1989, 49(11): 3134-3138.
[6] Kohsaka T, et al. Periapical lesions in rats with streptozotocin-induced diabetes. J Endod. 1996, 22(8): 418-421.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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