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Cat. No. Name Size Price Add Cart
KI0830Sulfapyridine1 g$140

Chemical Characteristic

Product NameSulfapyridine
CAS No.144-83-2
Molecular Weight 249.29
FormulaC11H11N3O2S
Chemical Structure

Biological activities

Sulfapyridine is an antimicrobial agent. Sulfapyridine is a major metabolite of salicylazosulfapyridine. Sulfapyridine is shown to be strong inducer of kinetochore positive (KC+) micronucleus.[1] Sulfapyridine inhibits spontaneous cytotoxicity mediated by human natural killer (NK) cells. [2] Sulfapyridine suppresses superoxide radicals (O2-) radical production with an IC50 of > 3 mM. [3] Sulfapyridine mimics the paraaminobenzoic acid (PABA), which is a natural substrate required for the biosynthesis of folic acid. Sulfapyridine inhibits the activity of the enzyme dihydropteroate synthase (DHPS), which catalyzes the displacement of pyrophosphate from a pteridine substrate resulting in a covalent bond to the amino group of PABA. The MIC of sulfapyridine against Escherichia coli is < 1,027 µM. Sulfapyridine inhibits the growth of K562 cells with an IC50 of < 100 µM. [4] In vivo, sulfapyridine induces predominantly aneuploidogenic type damage. [1]

Protocols

Sulfapyridine is dissolved in water at pH 9 (the pH is adjusted with NaOH). [4]

References

[1] Witt KL, et al. Induction of kinetochore positive and negative micronuclei in mouse bone marrow cells by salicylazosulfapyridine and sulfapyridine. Mutat Res. 1992, 283(1): 53-57. 閵嗏偓閵嗏偓
[2] Shanahan F, et al. Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes. Immunopharmacology. 1986, 11(2): 111-118. 閵嗏偓閵嗏偓
[3] Kimura I, et al. Effects of BX661A, a new therapeutic agent for ulcerative colitis, on reactive oxygen species in comparison with salazosulfapyridine and its metabolite sulfapyridine. Arzneimittelforschung. 1998, 48(10): 1007-1011. 閵嗏偓閵嗏偓
[4] Marzano IM, et al. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth (III) with Sulfapyridine. Molecules. 2013, 18(2): 1464-1476. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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