Talampanel Inhibitor CAS No. 161832-65-1

Cat. No.	Name	Size	Price
KI1476	Talampanel	10 mg	$230
	Talampanel	25 mg	$460
	Talampanel	50 mg	$820

Chemical Characteristic

Product Name	Talampanel
CAS No.	161832-65-1
Molecular Weight	337.37
Formula	C₁₉H₁₉N₃O₃
Chemical Name	(R)-1-(5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepin-7-yl)ethanone
Smiles	C1(=NN([C@@H](Cc2c1cc1c(c2)OCO1)C)C(=O)C)c1ccc(cc1)N
Chemical Structure

Biological activities

Talampanel is a noncompetitive antagonist of the α-amino-3- hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) receptor. Talampanel has a broad spectrum of action in animal models of epilepsy and neuroprotection. Talampanel causes very little CNS impairment in maximum electroshock model, with an ED50 of 8.6 mg/kg in mice. Subprotective doses of talampanel enhance the protective effects of valproate, diphenylhydantoin, and phenobarbital in the mouse MES procedure. ^[1]Talampanel can be safely combined with standard radiation and temozolomide, which is beneficial in glioblastoma.^[2] Talampanel has a broad spectrum of anticonvulsant activity in animal seizures models, including maximal electroshock and pentylenetetrazole- induced seizures in mice, chemically and electrically kindled seizures in mice, and is effective in a mouse model of phenytoin (PHT)-resistant status epilepticus.^[3] After the occlusion Talampanel injection reduces the infarct size in rats and mice and has benefit in transient and permanent ischemia.^[4]

Protocols

Talampanel is suspended in saline containing 0.5% Tween-80. ^[4]

References

[1] Howes JF, et al. Talampanel. The Journal of the American Society for Experimental Neuro Therapeutics. 2007, 4: 126-129. [1] Grossman SA, et al. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol. 2009, 27 (25): 4155-4161. [4] Denes L, et al. Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia. Brain Res Bull. 2006. 31, 70 (3): 260-262.

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