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Cat. No. Name Size Price Add Cart
KI1377Tannic acid1 g$60

Chemical Characteristic

Product NameTannic acid
CAS No.1401-55-4
Molecular Weight 1701.2
FormulaC76H52O46
Smiles[C@@H]1([C@@H]([C@H]([C@@H](O[C@@H]1COC(=O)c1cc(c(c(c1)OC(=O)c1cc(c(c(c1)O)O)O)O)O)OC(=O)c1cc(c(c(c1)OC(=O)c1cc(c(c(c1)O)O)O)O)O)OC(=O)c1cc(c(c(c1)OC(=O)c1cc(c(c(c1)O)O)O)O)O)OC(=O)c1cc(c(c(c1)OC(=O)c1cc(c(c(c1)O)O)O)O)O)OC(=O)c1cc(c(c(c1)OC(=O)c1cc(c(c(c
Chemical Structure

Biological activities

Tannic acid is a potent chelator of iron ions. Tannic acid inhibits the degradation of 2-deoxyribose induced by 6 µM Fe (II) plus 100 µM H2O2 with an IC50 of 13 µM. Tannic acid has been described as having antimutagenic, anticarcinogenic and antioxidant activities. Tannic acid also inhibits 2-deoxyribose degradation mediated by Fe (III)-EDTA (iron = 50 µM) plus ascorbate. Tannic acid inhibits iron-mediated oxyradical formation like other iron chelators, such as desferrioxamine (DFO), 1, 10-phenanthroline and pyridoxal isonicotinoyl hydrazone (PIH). [1] Tannic acid agglutinates erythrocytes which have the ability to promote adsorption of proteins by erythrocytes. Tannic acid alters the surface properties of the red blood cells, changing them from a hydrophilic to a hydrophobic state. [2] Tannic acid interferes in the oxidation of succinate by inhibition of the carrier of succinate. Tannic acid strongly inhibits the ATPases of the enterocytes. [3]

Protocols

Fresh solutions of tannic acid are made in saline in vitro. [2]

References

[1] Lopes GK, et al. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta. 1999, 1472(1-2): 142-152.
[2] Boyden SV, et al. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951, 93(2): 107-120.
[3] Mitjavila S, et al. Tannic acid and oxidized tannic acid on the functional state of rat intestinal epithelium. J Nutr. 1977, 107(12): 2113-2121.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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