Taurine Inhibitor CAS No. 107-35-7

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KI0762	Taurine	10 g	$80

Chemical Characteristic

Product Name	Taurine
CAS No.	107-35-7
Molecular Weight	125.15
Formula	C₂H₇NO₃S
Chemical Structure

Biological activities

Taurine is a sulphonic amino acid present in high amounts in various tissues including cardiac and skeletal muscles. Taurine has different properties such as antioxidative, antimyotonic and antischaemic effects.Ki values of taurine for GABA_{A, GABA_{B receptors and taurine binding site of rabbit brain is 118.1, 0.8 and 0.23µM, respectively.^[1] In cardiac cells in vitro, taurine is an agonist of the Ca²⁺ current and delays rectifier K⁺ current at low internal Ca²⁺ concentration (10 nM) in turn promoting the shortening of the action potential duration (APD) with an inotropic effect.^[2] Furthermore, taurine blocks ATP-sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor.^[3] In vivo, taurine can influence (and possibly reverse) defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in Zucker diabetic fatty rats.^[4] In another model of spontaneous type 2 diabetes, taurine significantly decreases weight and decreases blood sugar in the Otsuka Long-Evans Tokushima Fatty rat.^[5] Taurine administration to diabetic rabbits also results in 30% decrease in serum glucose levels.^[6] Chronic treatment of high-fat mice with taurine improves the abnormal profile of the serum lipoproteins, and thereby retards the progression of atherosclerosis.^[7]}}

Protocols

In vivo: Taurine is dissolved in drinking water at 1% (w/v).^[7]

References

[1] Frosini M, et al. Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain. Br J Pharmacol. 2003, 138(6): 1163-1171. 閵嗏偓閵嗏偓 [2] Satoh H, et al. Actions of taurine on the L-type Ca²⁺ channel current in guinea pig ventricular cardiomyocytes. J Cardiovasc Pharmacol. 1997, 30(6): 711-716. 閵嗏偓閵嗏偓 [3] Tricarico D, et al. Taurine blocks ATP-sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor. Br J Pharmacol. 2000, 130(4): 827-834. 閵嗏偓閵嗏偓 [4] Li F, et al. Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats. Neurobiol Dis. 2006, 22(3): 669-676. 閵嗏偓閵嗏偓 [5] Nakaya Y, et al. Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr. 2000, 71(1): 54-58. [6] Winiarska K, et al. Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie. 2009, 91(2): 261-270. [7] Murakami S, et al. Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet. Life Sci. 1999, 64(1): 83-91. 閵嗏偓閵嗏偓

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