Teicoplanin Inhibitor CAS No. 61036-62-2

Cat. No.	Name	Size	Price	Add Cart
KI1376	Teicoplanin	200 mg	$520

Chemical Characteristic

Product Name	Teicoplanin
CAS No.	61036-62-2
Molecular Weight	1709.39
Formula	C₇₈H₇₇Cl₂N₈O₃₂R
Smiles	c1c2ccc(c1Cl)Oc1cc3cc(c1O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)C)Oc1ccc(cc1Cl)CC1C(=O)N[C@H](C(=O)N[C@H]3C(=O)N[C@H]3C(=O)N[C@@H]([C@@H]2O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(=O)C)C(=O)N[C@H](c2cc(c(cc2c2c(ccc3c2)O)OC2[C@H]([C@H]([C@@H]([C@H](
Chemical Structure

Biological activities

Teicoplanin is a drug for the treatment of C. difficile-associated diarrhea (CDAD).^[1] Teicoplanin is a valuable drug for the treatment of infections caused by methicillin-resistant staphylococci. Teicoplanin is more active than vancomycin against streptococci and enterococci and equally active against staphylococcus aureus but less active against coagulase-negative staphylococci. The distribution of teicoplanin MICs is wide, ranging from 0.5 to 32 µg/mL. ^[2] Teicoplanin has a longer half-life than vancomycin, it can be given as an intravenous bolus or by intramuscular injection, and nephrotoxicity and ototoxicity are relatively uncommon. Teicoplanin binds to the terminal D-Ala-D-Ala sequence of peptides forming the bacterial cell wall and, by stearically hindering the transglycosylation reaction, inhibits the formation of peptidoglycan. ^[3]

Protocols

Teicoplanin is dissolved in DMSO in vitro. ^[2]

References

[1] Wenisch C, et al. Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile-associated diarrhea. Clin Infect Dis. 1996, 22(5): 813-818. [2] Goldstein FW, et al. Percentages and distributions of teicoplanin- and vancomycin-resistant strains among coagulase-negative staphylococci. Antimicrob Agents Chemother. 1990, 34(5): 899-900. [3] Wood MJ, et al. Comparative safety of teicoplanin and vancomycin. J Chemother. 2000, 12 Suppl 5: 21-25.

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