Cat. No. Name Size Price Add Cart
KI1017Tenofovir Disoproxil Fumarate10 mg$154
Tenofovir Disoproxil Fumarate50 mg$496

Chemical Characteristic

Product NameTenofovir Disoproxil Fumarate
SynonymsViread, TDF
CAS No.202138-50-9
Molecular Weight 635.515
FormulaC23H34N5O14P
Chemical Name9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate
Smilesn1cnc2c(c1N)ncn2C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C C(=O)(/C=C/C(=O)O)O
Chemical Structure

Biological activities

Tenofovir Disoproxil Fumarate is a disoproxil fumarate salt of tenofovir. Tenofovir is a nucleotide analogue reverse transcriptase inhibitor. Tenofovir inhibits wild type HBV with an IC50 of 4.8 µM.[1] Tenofovir is used for the treatment of HIV. Tenofovir is also developed to treat chronic hepatitis B. Tenofovir has a long intracellular half-life of 95 hours. Tenofovir is a potent and competitive inhibitor of HBV polymerase with a Ki of 0.18 µM.[2] Tenofovir has a higher affinity for the viral DNA polymerases than for human cellular DNA polymerases α, β, γ, δ and ε. Tenofovir interferes with human nuclear DNA synthesis.[3]

References

[1] Villet S, et al. Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. J Hepatol. 2007, 46(3): 531-538.
[2] Delaney WE 4th, et al.Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus. Antimicrob Agents Chemother. 2006, 50(7): 2471-2477.
[3] Reynaud L, et al. Tenofovir and its potential in the treatment of hepatitis B virus. Ther Clin Risk Manag. 2009, 5(1): 177-185.

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