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Cat. No. Name Size Price Add Cart
KI0656Terbinafine100 mg$250

Chemical Characteristic

Product NameTerbinafine
SynonymsLamisil, Terbinex
CAS No.91161-71-6
Molecular Weight 291.43
FormulaC21H25N
Chemical Structure

Biological activities

Terbinafine is an allylamine derivative antimycotic compounds. Terbinafine is highly active against dermatophytes with MIC values ranging from 1 to 10 ng/mL. The MIC values of terbinafine against aspergilli are ranging from 0.05 to 1.56 µg/mL. The MIC values of terbinafine against Sporothrix schenckii are ranging from 0.1 to 0.4 µg/mL. The MIC values of terbinafine against yeasts are >0.1 µg/mL . Terbinafine displays a primary fungicidal action against dermatophytes, other filamentous fungi, and S. Schenckii.[1] For 259 C. albicans isolates, the MIC50 of terbinafine is 1 µg/mL, and the MIC90 is 4 µg/mL. Terbinafine is also highly active against Candida parapsilosis with MIC90 of 0.125 µg/mL. Terbinafine shows potentially interesting activity against isolates of Candida dubliniensis, Candida guilliermondii, Candida humicola, and Candida lusitaniae.[2] In nude mice implanted wtih COLO 205 cells, subsequent intraperitoneal injections of terbinafine (50 mg/kg) leads to obvious decline in tumor size, up to 50-60%.[3] Terbinafine is also effective in experimental fungal infections of laboratory animals.[4]

Protocols

In vivo: Terbinafine is dissolved in dimethyl sulfoxide and mixed with polyethylene glycol 400 and Aerosil in a proportion of 4:5:1.[4]

References

[1] Petranyi G, et al. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob Agents Chemother. 1987, 31(9): 1365-1368. 閵嗏偓閵嗏偓
[2] Ryder NS, et al. In vitro activities of terbinafine against cutaneous isolates of Candida albicans and other pathogenic yeasts. Antimicrob Agents Chemother. 1998, 42(5): 1057-1061.
[3] Lee WS, et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. Int J Cancer. 2003, 106(1): 125-137.
[4] Petranyi G, et al. Activity of terbinafine in experimental fungal infections of laboratory animals. Antimicrob Agents Chemother. 1987, 31(10): 1558-1561.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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